Infliximab and adalimumab concentrations and anti-drug antibodies in inflammatory bowel disease control using New Zealand assays

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Title

Infliximab and adalimumab concentrations and anti-drug antibodies in inflammatory bowel disease control using New Zealand assays

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Therapeutic drug monitoring of anti-tumour necrosis factor (TNF) drugs and anti-drug antibodies (ADA) is now recommended in the treatment of inflammatory bowel disease. However, assay types and drug concentration thresholds are still debated. To correlate inflammatory bowel disease activity in a New Zealand cohort with trough concentrations of infliximab and adalimumab, and ADA using locally developed competitive-binding enzyme-linked immunosorbent assays (ELISA) to establish threshold concen...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2019-04

Creator

Barclay, Murray L / Karim, Shwan / Helms, Esther T Johanna / Keating, Paula E / Hock, Barry / Stamp, Lisa K / Schultz, Michael

URL

https://hdl.handle.net/10523/28682

Related subjects

Adalimumab - blood / Adalimumab - therapeutic use / Adolescent / Adult / Aged / Anti-Inflammatory Agents - blood / Anti-Inflammatory Agents - therapeutic use / Antibodies, Neutralizing - blood / Binding, Competitive / Drug Monitoring - methods / Enzyme-Linked Immunosorbent Assay / Female / Gastrointestinal Agents - blood / Gastrointestinal Agents - therapeutic use / Humans / Inflammatory Bowel Diseases - drug therapy / Infliximab - blood / Infliximab - therapeutic use / Male / Middle Aged / New Zealand / ROC Curve / Tumor Necrosis Factor-alpha - antagonists & inhibitors / Young Adult

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