Safety and acceptability of clozapine and risperidone in progressive multiple sclerosis: a phase I, randomised, blinded, placebo-controlled trial

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Title

Safety and acceptability of clozapine and risperidone in progressive multiple sclerosis: a phase I, randomised, blinded, placebo-controlled trial

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Objective Because clozapine and risperidone have been shown to reduce neuroinflammation in humans and mice, the Clozapine and Risperidone in Progressive Multiple Sclerosis (CRISP) trial was conducted to determine whether clozapine and risperidone are suitable for progressive multiple sclerosis (pMS). Methods The CRISP trial (ACTRN12616000178448) was a blinded, randomised, placebo-controlled trial with three parallel arms (n=12/arm). Participants with pMS were randomised to clozapine (100-150 ...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2020-07-01

Creator

La Flamme, Anne C. / Abernethy, David / Sim, Dalice / Goode, Liz / Lockhart, Michelle / Bourke, David / Milner, Imogen / Garrill, Toni-Marie / Joshi, Purwa / Watson, Eloise / Smyth, Duncan / Lance, Sean / Connor, Bronwen

URL

https://hdl.handle.net/10523/28722

Related subjects

Clinical Neurology / Life Sciences & Biomedicine / Neurosciences & Neurology / Science & Technology

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