Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model

About this item

Title

Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Thiocyanate (SCN) is used by the innate immune system, but less is known about its impact on inflammation and oxidative stress. Granulocytes oxidize SCN to evolve the bactericidal hypothiocyanous acid, which we previously demonstrated is metabolized by mammalian, but not bacterial, thioredoxin reductase (TrxR). There is also evidence that SCN is dysregulated in cystic fibrosis (CF), a disease marked by chronic infection and airway inflammation. To investigate antiinflammatory effects of SCN, ...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2015-08

Creator

Chandler, Joshua D / Min, Elysia / Huang, Jie / McElroy, Cameron S / Dickerhof, Nina / Mocatta, Tessa / Fletcher, Ashley A / Evans, Christopher M / Liang, Liping / Patel, Manisha / Kettle, Anthony J / Nichols, David P / Day, Brian J

URL

https://hdl.handle.net/10523/31735

Related subjects

Administration, Inhalation / Animals / Anti-Bacterial Agents - administration & dosage / Anti-Bacterial Agents - pharmacology / Anti-Inflammatory Agents - administration & dosage / Anti-Inflammatory Agents - pharmacology / Cell Line / Cystic Fibrosis - drug therapy / Cystic Fibrosis - immunology / Cystic Fibrosis - metabolism / Drug Evaluation, Preclinical / Female / Lung - enzymology / Lung - microbiology / Male / Mice, Inbred C57BL / Oxidative Stress / Pneumonia, Bacterial - drug therapy / Pneumonia, Bacterial - enzymology / Pneumonia, Bacterial - immunology / Pseudomonas aeruginosa - immunology / Pseudomonas Infections - drug therapy / Pseudomonas Infections - enzymology / Pseudomonas Infections - immunology / Thiocyanates - administration & dosage / Thiocyanates - pharmacology / Thioredoxin-Disulfide Reductase - metabolism

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