A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy

About this item

Title

A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Epitope-based peptide vaccines encompass minimal immunogenic regions of protein antigens to allow stimulation of precisely targeted adaptive immune responses. However, because efficacy is largely determined by the functional status of antigen-presenting cells (APCs) that acquire and present peptides to cells of the adaptive immune system, adjuvant compounds are needed to enhance immunogenicity. We present here a vaccine consisting of an allergen-derived peptide conjugated to a prodrug of the ...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2014-11-01

Creator

Anderson, Regan J / Tang, Ching-wen / Daniels, Naomi J / Compton, Benjamin J / Hayman, Colin M / Johnston, Karen A / Knight, Deborah A / Gasser, Olivier / Poyntz, Hazel C / Ferguson, Peter M / Larsen, David S / Ronchese, Franca / Painter, Gavin F / Hermans, Ian F

URL

https://hdl.handle.net/10523/31181

Related subjects

Adjuvants, Immunologic / Allergens - administration & dosage / Allergens - chemistry / Allergens - immunology / Animals / Anti-Inflammatory Agents - metabolism / Anti-Inflammatory Agents - pharmacology / Anti-Inflammatory Agents - therapeutic use / Antigen-Presenting Cells - drug effects / Antigen-Presenting Cells - immunology / Disease Models, Animal / Female / Galactosylceramides - metabolism / Galactosylceramides - pharmacology / Galactosylceramides - therapeutic use / Hypersensitivity - drug therapy / Hypersensitivity - immunology / Immunoglobulin E - blood / Inflammation - drug therapy / Male / Mice / Mice, Inbred C57BL / Molecular Conformation / Natural Killer T-Cells - cytology / Natural Killer T-Cells - drug effects / Natural Killer T-Cells - immunology / Peptides - administration & dosage / Peptides - chemistry / Peptides - immunology / Prodrugs - chemistry / Prodrugs - metabolism / T-Lymphocytes, Cytotoxic - drug effects / T-Lymphocytes, Cytotoxic - immunology / Vaccines - administration & dosage / Vaccines - chemical synthesis / Vaccines - chemistry / Vaccines - immunology

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