Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus

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Title

Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus

Content partner

University of Otago

Collection

Otago University Research Archive

Description

The Bienenstock, Cooper and Munro (BCM) computational model, which incorporates a metaplastic sliding threshold for LTP induction, accounts well for experience-dependent changes in synaptic plasticity in the visual cortex. BCM-like metaplasticity over a shorter timescale has also been observed in the hippocampus, thus providing a tractable experimental preparation for testing specific predictions of the model. Here, using extracellular and intracellular electrophysiological recordings from ac...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2012-05-16

Creator

Hulme, Sarah R / Jones, Owen D / Ireland, David R / Abraham, Wickliffe C

URL

https://hdl.handle.net/10523/33210

Related subjects

Action Potentials - physiology / Animals / Atropine - pharmacology / CA1 Region, Hippocampal - drug effects / CA1 Region, Hippocampal - physiology / Calcium - physiology / Calcium Channels, L-Type - physiology / In Vitro Techniques / Long-Term Potentiation - physiology / Long-Term Synaptic Depression - physiology / Male / Models, Neurological / Muscarinic Antagonists - pharmacology / Neural Inhibition - physiology / Neuronal Plasticity - physiology / Pirenzepine - pharmacology / Rats / Rats, Sprague-Dawley / Receptor, Muscarinic M1 - physiology / Receptors, Metabotropic Glutamate - physiology / Receptors, N-Methyl-D-Aspartate - physiology / Synaptic Potentials - physiology

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