Synthesis and biological screening of some pyridine derivatives as anti-malarial agents

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Title

Synthesis and biological screening of some pyridine derivatives as anti-malarial agents

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Two series of pyridine derivatives were synthesised and evaluated for their in vivo anti-malarial activity against Plasmodium berghei. The anti-malarial activity was determined in vivo by applying 4-day standard suppressive test using chloroquine (CQ)-sensitive P. berghei ANKA strain-infected mice. Compounds 2a, 2g and 2h showed inhibition of the parasite multiplication by 90, 91 and 80%, respectively, at a dose level of 50 µmol/kg. Moreover, The most active compounds (2a, 2g and 2h) were tes...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2012-02

Creator

Bekhit, Adnan A / Hymete, Ariaya / Damtew, Ashenafi / Mohamed, Abdel Maaboud I / Bekhit, Alaa El-Din A

URL

https://hdl.handle.net/10523/32932

Related subjects

Animals / Antimalarials - chemical synthesis / Antimalarials - chemistry / Antimalarials - pharmacology / Crystallography, X-Ray / Drug Evaluation, Preclinical / Male / Mice / Models, Molecular / Molecular Structure / Parasitic Sensitivity Tests / Plasmodium berghei - drug effects / Pyridines - chemical synthesis / Pyridines - chemistry / Pyridines - pharmacology / Stereoisomerism / Structure-Activity Relationship

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