The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

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Title

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Background: Increased oxidative stress and subsequent mitochondrial damage are important pathways for liver damage in chronic hepatitis C virus (HCV) infection; consequently, therapies that decrease mitochondrial oxidative damage may improve outcome. The mitochondria-targeted anti-oxidant mitoquinone combines a potent anti-oxidant with a lipophilic cation that causes it to accumulate several-hundred fold within mitochondria in vivo. Aims: In this phase II study, we investigated the effect of ...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2010-08

Creator

Gane, Edward J. / Weilert, Frank / Orr, David W. / Keogh, Geraldine F. / Gibson, Michael / Lockhart, Michelle M. / Frampton, Christopher M. / Taylor, Kenneth M. / Smith, Robin A. J. / Murphy, Michael P.

URL

https://hdl.handle.net/10523/32959

Related subjects

Gastroenterology & Hepatology / Life Sciences & Biomedicine / Science & Technology

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