The Pharmacokinetics and Pharmacogenetics of the Antiemetic Cyclizine in Palliative Care Patients

About this item

Title

The Pharmacokinetics and Pharmacogenetics of the Antiemetic Cyclizine in Palliative Care Patients

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Cyclizine, an antihistaminic antiemetic, is commonly used in palliative care. Its pharmacokinetics have been poorly studied, and its metabolic pathway is unknown but may involve the genetically controlled cytochrome P450 2D6 (CYP2D6). If this is the case, the metabolic ratio of cyclizine to norcyclizine and efficacy/adverse effects may vary between patients according to their CYP2D6 genotype. To deduce the pharmacokinetics and antiemetic/sedative effects of cyclizine and relate these and its ...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2012-03-01

Creator

Vella-Brincat, Jane W.A. / Begg, Evan J. / Jensen, Berit P. / Chin, Paul K.L. / Roberts, Rebecca L. / Fairhall, Mary / Macleod, Sandy (A.D.) / Reid, Kate

URL

https://hdl.handle.net/10523/34219

Related subjects

Antiemetic / CYP2D6 / drug concentrations / nausea

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