Transforming growth factor-beta blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction

About this item

Title

Transforming growth factor-beta blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction

Content partner

University of Otago

Collection

Otago University Research Archive

Description

After myocardial infarction (MI), the heart may undergo progressive ventricular remodeling, resulting in a deterioration of cardiac function. TGF-beta is a key cytokine that both initiates and terminates tissue repair, and its sustained production underlies the development of tissue fibrosis, particularly after MI. We investigated the effects of a novel orally active specific inhibitor of the TGF-beta receptor 1 (SD-208) in an experimental model of MI. Mice underwent ligation of the left coro...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2008-11-01

Creator

Ellmers, Leigh J / Scott, Nicola J A / Medicherla, Satyanarayana / Pilbrow, Anna P / Bridgman, Paul G / Yandle, Timothy G / Richards, A Mark / Protter, Andrew A / Cameron, Vicky A

URL

https://hdl.handle.net/10523/35134

Related subjects

Animals / Cardiomegaly - genetics / Cardiomegaly - metabolism / Cardiomegaly - pathology / Down-Regulation - drug effects / Drug Evaluation, Preclinical / Gene Expression Regulation - drug effects / Heart - drug effects / Kidney - drug effects / Kidney - metabolism / Kidney - pathology / Male / Mice / Mice, Inbred C57BL / Myocardial Infarction - drug therapy / Myocardial Infarction - metabolism / Myocardial Infarction - physiopathology / Myocardium - metabolism / Myocardium - pathology / Pteridines - pharmacology / Pteridines - therapeutic use / Receptors, Transforming Growth Factor beta - antagonists & inhibitors / Renin - blood / Renin - metabolism / Renin-Angiotensin System - drug effects / Renin-Angiotensin System - physiology / Transforming Growth Factor beta - antagonists & inhibitors / Transforming Growth Factor beta - physiology / Ventricular Remodeling - drug effects

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