Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis

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Title

Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Sepsis is a complex clinical syndrome resulting from a harmful host inflammatory response to infection. Chemokines and their receptors play a key role in the pathogenesis of sepsis. BX471 is a potent nonpeptide CC chemokine receptor-1 (CCR1) antagonist in both human and mouse. The aim of the present study was to evaluate the effect of prophylactic and therapeutic treatment with BX471 on cecal ligation and puncture-induced sepsis in the mouse and to investigate the underlying mechanisms. In se...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2007-04

Creator

He, Min / Horuk, Richard / Moochhala, Shabbir M / Bhatia, Madhav

URL

https://hdl.handle.net/10523/35351

Related subjects

Animals / Anti-Inflammatory Agents - pharmacology / Anti-Inflammatory Agents - therapeutic use / Appendix - surgery / Chemokine CCL4 / Disease Models, Animal / Disease Progression / E-Selectin - genetics / E-Selectin - metabolism / Gene Expression - drug effects / Intercellular Adhesion Molecule-1 - genetics / Intercellular Adhesion Molecule-1 - metabolism / Ligation / Liver - drug effects / Liver - metabolism / Liver - pathology / Lung - drug effects / Lung - metabolism / Lung - pathology / Macrophage Inflammatory Proteins - biosynthesis / Male / Mice / Neutrophil Infiltration - drug effects / P-Selectin - genetics / P-Selectin - metabolism / Peroxidase - metabolism / Phenylurea Compounds - pharmacology / Phenylurea Compounds - therapeutic use / Piperidines - pharmacology / Piperidines - therapeutic use / Receptors, CCR1 / Receptors, Chemokine - antagonists & inhibitors / Receptors, Chemokine - metabolism / RNA, Messenger - metabolism / Sepsis - genetics / Sepsis - metabolism / Sepsis - pathology / Sepsis - prevention & control / Sepsis - therapy / Time Factors

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