Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

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Title

Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

Content partner

University of Otago

Collection

Otago University Research Archive

Description

The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin, adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist of one of two GPCRs, the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CLR). Further diversity arises from heterodimerization of these GPCRs with one of three receptor activity-modifying proteins (RAMPs). This gives the CGRP receptor (CLR/RAMP1), the AM and AM receptors (CLR/RAMP2 or RAMP3) and the AMY AM...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2018-01

Creator

Hay, Debbie L / Garelja, Michael L / Poyner, David R / Walker, Christopher S

URL

https://hdl.handle.net/10523/37159

Related subjects

Animals / Calcitonin - chemistry / Calcitonin - metabolism / Calcitonin - pharmacology / Calcitonin Gene-Related Peptide - chemistry / Calcitonin Gene-Related Peptide - metabolism / Calcitonin Gene-Related Peptide - pharmacology / Calcitonin Receptor-Like Protein - chemistry / Calcitonin Receptor-Like Protein - metabolism / Humans / Protein Binding - physiology / Protein Structure, Secondary / Receptors, Calcitonin - chemistry / Receptors, Calcitonin - metabolism / Receptors, Calcitonin Gene-Related Peptide - chemistry / Receptors, Calcitonin Gene-Related Peptide - metabolism

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