The biology and pathogenesis of vivax malaria

About this item

Title

The biology and pathogenesis of vivax malaria

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Most asexual vivax parasites accumulate in the reticulocyte-rich spleen, replicating in an endosplenic life cycle. This reservoir contributes to systemic inflammation and anemia, and helps maintain chronic infections and transmission.Plasmodium vivax merozoites preferentially invade nascent reticulocytes over mature reticulocytes through newly identified invasion pathways.Humanized mice and hepatocyte culture systems are characterizing hypnozoite biology, and new approaches for anti-relapse t...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2024-07-01

Creator

Anstey, Nicholas M. / Tham, Wai-Hong / Shanks, G. Dennis / Poespoprodjo, Jeanne R. / Russell, Bruce M. / Kho, Steven

URL

https://hdl.handle.net/10523/40083

Related subjects

biology / hidden biomass / life cycle / pathophysiology / Plasmodium vivax / spleen

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