Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting endogenous growth factors

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Title

Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting endogenous growth factors

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Impaired wound healing due to insufficient cell proliferation and angiogenesis is a significant physical and psychological burden to patients worldwide. Therapeutic delivery of exogenous growth factors (GFs) at high doses for wound repair is non-ideal as GFs have poor stability in proteolytic wound environments. Here, we present a two-stage strategy using bioactive sucralfate-based microneedle (SUC-MN) for delivering interleukin-4 (IL-4) to accelerate wound healing. In the first stage, SUC-MN...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2024-12

Creator

Le, Zhicheng / Ramos, Mayk Caldas / Shou, Yufeng / Li, Renee R. / Cheng, Hong Sheng / Jang, Clarisse JM / Liu, Ling / Xue, Chencheng / Li, Xianlei / Liu, Hong / Lim, Chwee Teck / Tan, Nguan Soon / White, Andrew D. / Charles, Christopher John / Chen, Yongming / Liu, Zhijia / Tay, Andy

URL

https://hdl.handle.net/10523/40860

Related subjects

Bioactive / Growth factors / Microneedle / Sucralfate / Wound healing

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