Research paper
Characterizing the amyloid core region of the tumor suppressor protein p16INK4a using a limited proteolysis and peptide-based approach
About this item
- Title
- Characterizing the amyloid core region of the tumor suppressor protein p16INK4a using a limited proteolysis and peptide-based approach
- Content partner
- University of Otago
- Collection
- Otago University Research Archive
- Description
The human tumor suppressor p16INK4a is a small monomeric protein that can form amyloid structures. Formation of p16INK4a amyloid fibrils is induced by oxidation which creates an intermolecular disulfide bond. The conversion into amyloid is associated with a change from an all α-helical structure into β-sheet fibrils. Currently, structural insights into p16INK4a amyloid fibrils are lacking. Here, we investigate the amyloid-forming regions of this tumor suppressor using isotope-labeling limited...
- Format
- Research paper
- Research format
- Scholarly text / Journal article
- Thesis level
- Article
- Date created
- 2024-08-14
- Creator
- Heath, Sarah G. / Naughton, Jennifer D. / Magon, Nicholas J. / Gray, Shelby G. / Smith, Briana R. / Morris, Vanessa K. / Göbl, Christoph
- URL
- https://hdl.handle.net/10523/41445
- Related subjects
- amyloid / mass spectrometry / p16INK4a / protein oxidation / protein stability
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Copyright © The Author(s) 2024. This work was first published in Journal of Biological Chemistry (Elsevier). This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://www.creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, provided that the original work is properly attributed to the creator(s) and the source, a link to the Creative Commons license is provided, and any changes made are indicated.
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Report this itemDigitalNZ brings together more than 30 million items from institutions so that they are easy to find and use. This information is the best information we could find on this item. This item was added on 22 August 2024, and updated 23 May 2025.
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