A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts

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Title

A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Cystic fibrosis (CF) is a genetic disease caused by the mutations of cystic fibrosis transmembrane conductance regulator (CFTR), the cystic fibrosis transmembrane conductance regulator gene. Cftr is a critical ion channel expressed in the apical membrane of mouse salivary gland striated duct cells. Although Cftr is primarily a Cl- channel, its knockout leads to higher salivary Cl- and Na+ concentrations and lower pH. Mouse experiments show that the activation of Cftr upregulates epithelial Na...

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Format

Research paper

Research format

Journal article

Creator

Su, Shan / Wahl, Amanda / Rugis, John / Suresh, Vinod / Yule, David I / Sneyd, James

URL

https://hdl.handle.net/2292/69868

Related subjects

Cell Membrane / Animals / Mice / Cystic Fibrosis / Sodium / Cystic Fibrosis Transmembrane Conductance Regulator / Antiporters / Models, Theoretical / Epithelial Sodium Channels / Sulfate Transporters / CFTR / ion channels / mathematical modeling / salivary gland / 3208 Medical Physiology / 32 Biomedical and Clinical Sciences / Rare Diseases / Digestive Diseases / Genetics / Dental/Oral and Craniofacial Disease / Lung / 2.1 Biological and endogenous factors / Congenital / Science & Technology / Life Sciences & Biomedicine / Gastroenterology & Hepatology / Physiology / DEPENDENT HCO3-TRANSPORT / ION-TRANSPORT / CHANNELS / NA+ / SECRETION / ABSORPTION / MECHANISMS / EXCHANGER / MEMBRANE / ACINAR / 0606 Physiology / 1116 Medical Physiology / 3202 Clinical sciences

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