Oral delivery of bovine lactoferrin by using pectin- and chitosan-modified liposomes and solid lipid particles: improvement of stability of lactoferrin

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Title

Oral delivery of bovine lactoferrin by using pectin- and chitosan-modified liposomes and solid lipid particles: improvement of stability of lactoferrin

Content partner

Lincoln University

Collection

Lincoln University Research Archive

Description

A critical problem associated with delivery of bovine lactoferrin (bLf) by the oral route is low bioavailability, which is derived from the enzymatic degradation in the gastrointestinal tract and poor permeation across the intestinal epitheliums. Particulate carrier systems have been identified to protect bLf against proteolysis via encapsulation. This study aimed to evaluate the physico-chemical stability of bLf loaded liposomes and solid lipid particles (SLPs) modified by pectin and chitosa...

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Format

Research Paper

Research format

Journal article

Date created

2015-10

Creator

Yao, X / Bunt, Craig / Cornish, J / Quek, S-Y / Wen, J

URL

https://hdl.handle.net/10182/8867

Related subjects

drug delivery / ADMET / nanotechnology / drug discovery / protein structure / Animals / Cattle / Chitosan / Pectins / Lactoferrin / Liposomes / Administration, Oral / Protein Stability / Biochemistry and cell biology / Medicinal and biomolecular chemistry

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