Developmental toxicity, EROD, and CYP1A mRNA expression in zebrafish embryos exposed to dioxin-like PCB126

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Title

Developmental toxicity, EROD, and CYP1A mRNA expression in zebrafish embryos exposed to dioxin-like PCB126

Content partner

Lincoln University

Collection

Lincoln University Research Archive

Description

© 2014 Wiley Periodicals, Inc. Dioxin-like PCB126 is a persistent organic pollutant that causes a range of syndromes including developmental toxicity. Dioxins have a high affinity for aryl hydrocarbon receptor (AhR) and induce cytochrome P4501A (CYP1A). However, the role of CYP1A activity in developmental toxicity is less clear. To better understand dioxin induced developmental toxicity, we exposed zebrafish (Danio rerio) embryos to PCB126 at concentrations of 0, 16, 32, 64, and 128 μg L⁻¹ fr...

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Format

Research Paper

Research format

Journal article

Date created

2016-02

Creator

Liu, H / Nie, F-H / Lin, H-Y / Ma, Y / Ju, X-H / Chen, J-J / Gooneratne, R

URL

https://hdl.handle.net/10182/7832

Related subjects

PCB126 / zebrafish embryo / developmental toxicity / EROD / CYP1A / Yolk Sac / Embryo, Nonmammalian / Animals / Abnormalities, Drug-Induced / Polychlorinated Biphenyls / Aryl Hydrocarbon Hydroxylases / Cytochrome P-450 CYP1A1 / RNA, Messenger / Environmental Pollutants / Teratogens / Larva / Heart Rate / Dose-Response Relationship, Drug / Fisheries Sciences / Fish Physiology and Genetics / Biological sciences / Chemical sciences / Environmental sciences

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