Computational experiments reveal the efficacy of targeting CDK2 and CKIs for significantly lowering cellular senescence bar for potential cancer treatment

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Title

Computational experiments reveal the efficacy of targeting CDK2 and CKIs for significantly lowering cellular senescence bar for potential cancer treatment

Content partner

Lincoln University

Collection

Lincoln University Research Archive

Description

Lowering the threshold of cellular senescence, the process employed by cells to thwart abnormal cell proliferation, though inhibition of CDK2 or Skp2 (regulator of CDK inhibitors) has been recently suggested as a potential avenue for cancer treatment. In this study, we employ a published mathematical model of G1/S transition involving the DNA-damage signal transduction pathway to conduct carefully constructed computational experiments to highlight the effectiveness of manipulating cellular se...

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Format

Research Paper

Research format

Journal article

Date created

2013-02

Creator

Ling, H / Samarasinghe, Sandhya / Kulasiri, Don

URL

https://hdl.handle.net/10182/8678

Related subjects

cancer / cellular senescence / computational models / G1/S checkpoint pathway / DNA damage signal transduction pathway / senescence pathway / cell cycle regulation / systems biology / Animals / Humans / Neoplasms / Antineoplastic Agents / Treatment Outcome / Drug Delivery Systems / Drug Therapy, Computer-Assisted / Models, Biological / Computer Simulation / Cyclin-Dependent Kinase Inhibitor Proteins / Cyclin-Dependent Kinase 2 / Cellular Senescence / Biochemistry and Cell Biology / Cancer Cell Biology / Medical Biochemistry and Metabolomics not elsewhere classified / Biological sciences / Engineering

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