Phenotypic‐based Discovery and Exploration of a Resorufin Scaffold with Activity against Mycobacterium Tuberculosis

About this item

Title

Phenotypic‐based Discovery and Exploration of a Resorufin Scaffold with Activity against Mycobacterium Tuberculosis

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Tuberculosis remains a leading cause of death by infectious disease. The long treatment regimen and the spread of drug‐resistant strains of the causative agent Mycobacterium tuberculosis (Mtb) necessitates the development of new treatment options. In a phenotypic screen, a nitrofuran‐resorufin conjugate 1 was identified as a potent sub‐micromolar inhibitor of whole cell Mtb. Complete loss of activity was observed for this compound in Mtb mutants affected in enzyme cofactor F420 biosynthesis (...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2024-09-09

Creator

Tran, Eric / Li, Lucy / Cheung, Chen-Yi / Carter, Glen P / Gable, Robert W / West, Nicholas P / Kaur, Amandeep / Gee, Yi Sing / Cook, Gregory / Baell, Jonathan B / Joerg, Manuela

URL

https://hdl.handle.net/10523/42325

Related subjects

drug discovery / infectious disease / resorufin / structure-activity relationships / tuberculosis

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