An accumulated mutation gained in mosquito cells enhances Zika virus virulence and fitness in mice.

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Title

An accumulated mutation gained in mosquito cells enhances Zika virus virulence and fitness in mice.

Content partner

Massey University

Collection

Massey Research Online

Description

Zika virus (ZIKV) remains a significant public health threat worldwide. A number of adaptive mutations have accumulated within the genome of ZIKV during global transmission, some of which have been linked to specific phenotypes. ZIKV maintains an alternating cycle of replication between mosquitoes and vertebrate hosts, but the role of mosquito-specific adaptive mutations in ZIKV has not been well investigated. In this study, we demonstrated that serial passaging of ZIKV in mosquito Aag2 cells...

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Format

Research paper

Research format

Journal article

Date created

2024-10-16

Creator

Fan X-X / Li R-T / Zhu Y-B / Chen Q / Li X-F / Cao T-S / Zhao H / Cheng G / Qin C-F

URL

https://hdl.handle.net/10179/71975

Related subjects

accumulated mutation / fitness / mammal / mosquito / virulence / Zika virus

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