Zebrafish Optical Development Requires Regulated Water Permeability by Aquaporin 0

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Title

Zebrafish Optical Development Requires Regulated Water Permeability by Aquaporin 0

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

PurposeOptical development of the zebrafish eye relies on the movement of the highly refractive lens nucleus from an anterior to a central location in the optical axis during development. We have shown that this mechanism in turn depends on the function of Aquaporin 0a (Aqp0a), a multifunctional and extremely abundant protein in lens fiber cell membranes. Here, we probe the specific cellular functions necessary for rescuing lens nucleus centralization defects in aqp0a-/- null mutants by stabl...

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Format

Research paper

Research format

Journal article

Creator

Safrina, Olga / Vorontsova, Irene / Donaldson, Paul J / Schilling, Thomas F

URL

https://hdl.handle.net/2292/70633

Related subjects

Lens, Crystalline / Animals / Animals, Genetically Modified / Zebrafish / Calcium / Water / Aquaporins / Eye Proteins / Zebrafish Proteins / Gene Expression Regulation, Developmental / Permeability / 32 Biomedical and Clinical Sciences / 3212 Ophthalmology and Optometry / Pediatric / Congenital Structural Anomalies / Eye Disease and Disorders of Vision / Science & Technology / Life Sciences & Biomedicine / Ophthalmology / Aquaporin 0 (Aqp0a) / water permeability / lens development / optical development / CELL-ADHESION FUNCTION / PH / 06 Biological Sciences / 11 Medical and Health Sciences

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