Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish

About this item

Title

Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Cohesin complex is essential for cell division and for regulating cell type-specific gene expression programs. Mutations in genes encoding the cohesin subunits are associated with hematological malignancies, pre-leukemia and clonal hematopoiesis of indeterminate potential. In this study, we examined how cohesin mutation impacts hematopoiesis using adult zebrafish that carry heterozygous germline nonsense mutation in the cohesin subunit, rad21 ( rad21+/-) that is orthologous to human RAD21. Si...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2024-11-16

Creator

Gimenez, Gregory / Kalev-Zylinska, Maggie L / Morison, Ian / Bohlander, Stefan K / Horsfield, Julia A / Antony, Jisha

URL

https://hdl.handle.net/10523/43765

Related subjects

RAD21 / cohesin / hematopoiesis / leukemia / myeloid dysplastic syndrome

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