Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

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Title

Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants robustly associated with the trait have not been identified. The present study by the Broad Antisocial Behavior Consortium (BroadABC) meta-analyzed data from 28 discovery samples (N = 85,359) and five independent replication samples (N = 8058) with genotypic data and broad measures of ASB. We identified the first significant genetic associations with broad ASB, involving common intronic variants in th...

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Format

Research paper

Research format

Scholarly text / Journal article

Thesis level

Article

Date created

2022-11-01

Creator

Tielbeek, Jorim J / Uffelmann, Emil / Williams, Benjamin S / Colodro-Conde, Lucía / Gagnon, Éloi / Mallard, Travis T / Levitt, Brandt E / Jansen, Philip R / Johansson, Ada / Sallis, Hannah M / Pistis, Giorgio / Saunders, Gretchen R B / Allegrini, Andrea G / Rimfeld, Kaili / Konte, Bettina / Klein, Marieke / Hartmann, Annette M / Salvatore, Jessica E / Nolte, Ilja M / Demontis, Ditte / Malmberg, Anni L K / Burt, S Alexandra / Savage, Jeanne E / Sugden, Karen / Poulton, Richie / Harris, Kathleen Mullan / Vrieze, Scott / McGue, Matt / Iacono, William G / Mota, Nina Roth / Mill, Jonathan / Viana, Joana F / Mitchell, Brittany L / Morosoli, Jose J / Andlauer, Till F M / Ouellet-Morin, Isabelle / Tremblay, Richard E / Côté, Sylvana M / Gouin, Jean-Philippe / Brendgen, Mara R / Dionne, Ginette / Vitaro, Frank / Lupton, Michelle K / Martin, Nicholas G / Castelao, Enrique / Räikkönen, Katri / Eriksson, Johan G / Lahti, Jari / Hartman, Catharina A / Oldehinkel, Albertine J / Snieder, Harold / Liu, Hexuan / Preisig, Martin / Whipp, Alyce / Vuoksimaa, Eero / Lu, Yi / Jern, Patrick / Rujescu, Dan / Giegling, Ina / Palviainen, Teemu / Kaprio, Jaakko / Harden, Kathryn Paige / Munafò, Marcus R / Morneau-Vaillancourt, Geneviève / Plomin, Robert / Viding, Essi / Boutwell, Brian B / Aliev, Fazil / Dick, Danielle M / Popma, Arne / Faraone, Stephen V / Børglum, Anders D / Medland, Sarah E / Franke, Barbara / Boivin, Michel / Pingault, Jean-Baptiste / Glennon, Jeffrey C / Barnes, J C / Fisher, Simon E / Moffitt, Terrie E / Caspi, Avshalom / Polderman, Tinca J C / Posthuma, Danielle / COGA Consortium

URL

https://hdl.handle.net/10523/43947

Related subjects

Aggression - psychology / Antisocial Personality Disorder - genetics / Conduct Disorder - genetics / Conduct Disorder - psychology / Genome-Wide Association Study / Membrane Proteins - genetics / Multifactorial Inheritance - genetics / Nerve Tissue Proteins - genetics / neuroscience

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Copyright © Springer Nature 2022. All rights reserved. This work was first published in Molecular Psychiatry (Springer). The open access link to the subscription article is provided under the Springer Nature SharedIt Content-Sharing Initiative (https://www.springernature.com/gp/researchers/sharedit) making the view-only full-text article freely and legally accessible to anyone for research purposes and private study via the link: https://rdcu.be/d23jo

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