Research paper
Efficacy, immunogenicity, and safety of an investigational maternal respiratory syncytial virus prefusion F protein-based vaccine
About this item
- Title
- Efficacy, immunogenicity, and safety of an investigational maternal respiratory syncytial virus prefusion F protein-based vaccine
- Content partner
- University of Otago
- Collection
- Otago University Research Archive
- Description
Background: In this phase 3 trial of an investigational maternal respiratory syncytial virus prefusion F protein-based vaccine (RSVPreF3-Mat), a higher rate of preterm birth was observed in the vaccine (6.8%) versus the placebo group (4.9%). Trial enrollment and vaccination were stopped. Results of investigations into this safety signal were reported previously. Here, we describe end-of-trial efficacy, immunogenicity, and safety results.
- Format
- Research paper
- Research format
- Scholarly text / Journal article
- Thesis level
- Article
- Date created
- 2025-01-29
- Creator
- Banooni, Peyman / Gonik, Bernard / Epalza, Cristina / Reyes, Osvaldo / Madhi, Shabir A / Gomez-Go, Grace Devota / Zaman, Khalequ / Llapur, Conrado Juan / López-Medina, Eduardo / Stanley, Thorsten / Kantele, Anu / Huang, Li-Min / Mussi-Pinhata, Marisa Márcia / Dewulf, Jonas / Langley, Joanne M / Seidl, Claudia / Ota, Martin / Kirabo, Martha / Henry, Ouzama / Anspach, Bruno / Kim, Joon Hyung / Dieussaert, Ilse / Picciolato, Marta / GRACE study group
- URL
- https://hdl.handle.net/10523/44868
- Related subjects
- preterm birth / prefusion F protein / safety / maternal immunization / transplacental transfer / respiratory syncytial virus / efficacy
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Copyright © The Author(s) 2025. This work was first published in Clinical Infectious Diseases (Oxford University Press). This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://www.creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, provided that the original work is properly attributed to the creator(s) and the source, a link to the Creative Commons license is provided, and any changes made are indicated.
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Report this itemDigitalNZ brings together more than 30 million items from institutions so that they are easy to find and use. This information is the best information we could find on this item. This item was added on 10 February 2025, and updated 17 March 2025.
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