About this item
- Title
- DET1 dynamics underlie cooperative ubiquitination by CRL4 DET1-COP1 complexes
- Content partner
- University of Otago
- Collection
- Otago University Research Archive
- Description
Transcription factor ubiquitination is a decisive regulator of growth and development. The DET1-DDB1-DDA1 (DDD) complex associates with the Cullin-4 ubiquitin ligase (CRL4) and a second ubiquitin ligase, COP1, to control ubiquitination of transcription factors involved in neurological, metabolic, and immune cell development. Here, we report the structure of the human DDD complex, revealing a specific segment of DET1 that can recruit ubiquitin-conjugating (E2) enzymes. Structural variability a...
- Format
- Research paper
- Research format
- Scholarly text / Journal article
- Thesis level
- Article
- Date created
- 2025-02-28
- Creator
- Burgess, Abigail E / Loughran, Tarren A / Turk, Liam S / Nyvall, Hunter G / Dunlop, Jessica L / Jamieson, Sam A / Curry, Jack R / Burke, John E / Filipcik, Pavel / Brown, Simon H J / Mace, Peter D
- URL
- https://hdl.handle.net/10523/45112
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Copyright © The Author(s) 2025. This work was first published in Science Advances (American Association for the Advancement of Science). This is an Open Access article distributed under the terms of the Creative Commons‐Attribution‐NonCommercial License 4.0 International (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial use, reproduction, adaptation and distribution of the work in any medium provided the original work is properly attributed to the creator(s) and the source, a link to the Creative Commons license is provided, and any changes made are indicated.
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Report this itemDigitalNZ brings together more than 30 million items from institutions so that they are easy to find and use. This information is the best information we could find on this item. This item was added on 06 March 2025, and updated 17 March 2025.
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