Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

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Title

Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present a consensus treatment protocol based on the metabolic requirements of GBM cells for the two major fermentable fuels: glucose and glutamine. Glucose is a source of carbon and ATP synthesis for tumor growth through glycolysis, while glutamine provides nitrogen, carbon, and ATP synthesis through glutaminolysis. As no tumor can grow with...

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Format

Research paper

Research format

Journal article

Creator

Duraj, Tomás / Kalamian, Miriam / Zuccoli, Giulio / Maroon, Joseph C / D'Agostino, Dominic P / Scheck, Adrienne C / Poff, Angela / Winter, Sebastian F / Hu, Jethro / Klement, Rainer J / Hickson, Alicia / Lee, Derek C / Cooper, Isabella / Kofler, Barbara / Schwartz, Kenneth A / Phillips, Matthew CL / Champ, Colin E / Zupec-Kania, Beth / Tan-Shalaby, Jocelyn / Serfaty, Fabiano M / Omene, Egiroh / Arismendi-Morillo, Gabriel / Kiebish, Michael / Cheng, Richard / El-Sakka, Ahmed M / Pflueger, Axel / Mathews, Edward H / Worden, Donese / Shi, Hanping / Cincione, Raffaele Ivan / Spinosa, Jean Pierre / Slocum, Abdul Kadir / Iyikesici, Mehmet Salih / Yanagisawa, Atsuo / Pilkington, Geoffrey J / Chaffee, Anthony / Abdel-Hadi, Wafaa / Elsamman, Amr K / Klein, Pavel / Hagihara, Keisuke / Clemens, Zsófia / Yu, George W / Evangeliou, Athanasios E / Nathan, Janak K / Smith, Kris / Fortin, David / Dietrich, Jorg / Mukherjee, Purna / Seyfried, Thomas N

URL

https://hdl.handle.net/2292/73946

Related subjects

Humans / Glioblastoma / Brain Neoplasms / Glucose / Glutamine / Energy Metabolism / Glycolysis / Biomedical Research / Diet, Ketogenic / Cancer / Glutaminolysis / Metabolism / Precision medicine / Research design / Warburg Effect / 32 Biomedical and Clinical Sciences / 3211 Oncology and Carcinogenesis / Brain Cancer / Brain Disorders / Rare Diseases / Complementary and Integrative Health / Orphan Drug / Nutrition / Neurosciences / 5.1 Pharmaceuticals / 7 Affordable and Clean Energy / Science & Technology / Life Sciences & Biomedicine / Medicine, General & Internal / General & Internal Medicine / ORAL SODIUM PHENYLBUTYRATE / RESTING ENERGY-EXPENDITURE / CENTRAL-NERVOUS-SYSTEM / LONG-TERM SURVIVAL / I DOSE-ESCALATION / PHASE-I / KETONE-BODIES / CANCER-PATIENTS / GLUTAMINE-METABOLISM / WEIGHT-LOSS / 11 Medical and Health Sciences / 42 Health sciences

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