Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data

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Title

Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data

Content partner

University of Otago

Collection

Otago University Research Archive

Description

The clinical and epidemiological significance of HIV-associated Mycobacterium tuberculosis bloodstream infection (BSI) is incompletely understood. We hypothesised that M tuberculosis BSI prevalence has been underestimated, that it independently predicts death, and that sputum Xpert MTB/RIF has suboptimal diagnostic yield for M tuberculosis BSI. We did a systematic review and individual patient data (IPD) meta-analysis of studies performing routine mycobacterial blood culture in a prospectivel...

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Format

Research paper

Research format

Scholarly text / Journal article

Date created

2020-06

Creator

Barr, David A / Lewis, Joseph M / Feasey, Nicholas / Schutz, Charlotte / Kerkhoff, Andrew D / Jacob, Shevin T / Andrews, Ben / Kelly, Paul / Lakhi, Shabir / Muchemwa, Levy / Bacha, Helio A / Hadad, David J / Bedell, Richard / van Lettow, Monique / Zachariah, Rony / Crump, John A / Alland, David / Corbett, Elizabeth L / Gopinath, Krishnamoorthy / Singh, Sarman / Griesel, Rulan / Maartens, Gary / Mendelson, Marc / Ward, Amy M / Parry, Christopher M / Talbot, Elizabeth A / Munseri, Patricia / Dorman, Susan E / Martinson, Neil / Shah, Maunank / Cain, Kevin / Heilig, Charles M / Varma, Jay K / von Gottberg, Anne / Sacks, Leonard / Wilson, Douglas / Squire, S Bertel / Lalloo, David G / Davies, Gerry / Meintjes, Graeme

URL

https://hdl.handle.net/10523/22085

Related subjects

Bacteremia / HIV Infections - complications / Humans / Mortality / Mycobacterium tuberculosis / Prevalence / Tuberculosis - blood / Tuberculosis - complications

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