Substance P Promotes Leukocyte Infiltration in the Liver and Lungs of Mice with Sepsis: A Key Role for Adhesion Molecules on Vascular Endothelial Cells

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Title

Substance P Promotes Leukocyte Infiltration in the Liver and Lungs of Mice with Sepsis: A Key Role for Adhesion Molecules on Vascular Endothelial Cells

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Substance P (SP), encoded by the Tac1 gene, has been shown to promote leukocyte infiltration and organ impairment in mice with sepsis. Neurokinin-1 receptor (NK1R) is the major receptor that mediates the detrimental impact of SP on sepsis. This investigation studied whether SP affects the expression of adhesion molecules, including intercellular cell adhesion molecule-1 (ICAM1) and vascular cell adhesion molecule-1 (VCAM1) on vascular endothelial cells in the liver and lungs, contributing to ...

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Format

Research paper

Research format

Scholarly text / Journal article

Date created

2024-06-01

Creator

Zhu, Zhixing / Chambers, Stephen / Bhatia, Madhav

URL

https://hdl.handle.net/10523/41413

Related subjects

Biochemistry & Molecular Biology / Chemistry / Chemistry, Multidisciplinary / Life Sciences & Biomedicine / Physical Sciences / Science & Technology

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